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United States 


Inhibitor of ACE and leukotriene hydrolase
ALX-270-212-G001 1 g 61.00 USD
ALX-270-212-G005 5 g 155.00 USD
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Replaces Prod. #: BML-EI213

First orally active angiotensin-converting enzyme (ACE) inhibitor. IC50=2.14nM. Reversible and competitive inhibitor of LTA4 hydrolase (IC50=11μM). Inhibits angiogenesis. Antihypotensive agent.

Product Details

Alternative Name:(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
MI:14: 1774
Purity:≥98% (HPLC)
Appearance:White to off-white crystalline powder.
Solubility:Soluble in water, chloroform, dichloromethane or 100% ethanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Dysregulation of ACE-1 in Normal Aging and the Early Stages of Alzheimer’s Disease: R. MacLachlan, et al.; J. Gerontol. A Biol. Sci. Med. Sci. 77, 1775 (2022), Abstract;
Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids: R. Wang, et al.; Drug Des. Devel. Ther. 9, 4979 (2015), Application(s): Cell Culture, Abstract; Full Text

General Literature References

Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril: L. Orning, et al.; J. Biol. Chem. 266, 16507 (1991), Abstract;
Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes: L. Orning, et al.; J. Biol. Chem. 266, 1375 (1991), Abstract;