Replaces Prod. #: BML-EI213
First orally active angiotensin-converting enzyme (ACE) inhibitor. IC50=2.14nM. Reversible and competitive inhibitor of LTA4 hydrolase (IC50=11μM). Inhibits angiogenesis. Antihypotensive agent.
Product Details
| Alternative Name: | (2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline |
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| Formula: | C9H15NO3S |
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| MW: | 217.3 |
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| CAS: | 62571-86-2 |
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| MI: | 14: 1774 |
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| RTECS: | UY0550000 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble in water, chloroform, dichloromethane or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Dysregulation of ACE-1 in Normal Aging and the Early Stages of Alzheimer’s Disease: R. MacLachlan, et al.; J. Gerontol. A Biol. Sci. Med. Sci.
77, 1775 (2022),
Abstract;
Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids: R. Wang, et al.; Drug Des. Devel. Ther.
9, 4979 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
General Literature References
Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril: L. Orning, et al.; J. Biol. Chem.
266, 16507 (1991),
Abstract;
Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes: L. Orning, et al.; J. Biol. Chem.
266, 1375 (1991),
Abstract;
