Protein phosphotyrosine phosphatase inhibitor.
Product Details
| Formula: | K2[VO(O2)2C6H4NO3] |
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| MW: | 347.2 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Yellow crystalline solid. |
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| Solubility: | Soluble in DMSO or water. Note: This product is not stable in water. Starts decomposition immediately after solubilization. Rate of decomposition is slower in dry DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axi: M. Wang, et al.; iScience
25, 104009 (2022),
Abstract;
Signal amplification in growth cone gradient sensing by a double negative feedback loop among PTEN, PI(3,4,5)P3 and actomyosin: X. Li, et al.; Mol. Cell. Neurosci.
123, 103772 (2022),
Abstract;
Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein: A.M. Hartz, et al.; J. Pharmacol. Exp. Ther.
334, 467 (2010),
Abstract;
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Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction: K.T. Keyes, et al.; Am. J. Physiol. Heart Circ. Physiol.
298, H1198 (2010),
Abstract;
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Bisperoxovanadium compounds are potent PTEN inhibitors: A.C. Schmid, et al.; FEBS Lett.
566, 35 (2004),
Abstract;
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem.
269, 4596 (1994),
Abstract;
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