Potent and selective inhibitor of neuronal nitric oxide synthase (nNOS; NOS I) relative to inducible nitric oxide synthase (iNOS; NOS II) (3158-fold) and endothelial nitric oxide synthase (eNOS; NOS III) (149-fold).
Product Details
| Alternative Name: | N5-[Imino(propylamino)methyl]-L-ornithine |
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| Formula: | C9H20N4O2 |
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| MW: | 216.3 |
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| CAS: | 137361-05-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in PBS, pH 7.2 (25mg/ml), 100% ethanol (10mg/ml), DMSO (50μg/ml) or dimethyl formamide (50μg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least one year when stored at -20°C. We do not recommend storing aqueous solutions for more than one day. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle: C. Gowda, et al.; Nitric Oxide
11, 17 (2004),
Abstract;
The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice: D. Klamer, et al.; Eur. J. Pharmacol.
503, 103 (2004),
Abstract;
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms: R. Fedorov, et al.; J. Biol. Chem.
278, 45818 (2003),
Abstract;
Full Text
Cellular and enzymatic studies of N(omega)-propyl-l-arginine and S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform: G.R. Cooper, et al.; Arch. Biochem. Biophys.
375, 183 (2000),
Abstract;
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol.
58, 1026 (2000),
Abstract;
Full Text
Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases: Y. Lee, et al.; Bioorg. Med. Chem.
7, 1097 (1999),
Abstract;
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase: H. Huang, et al.; J. Med. Chem.
42, 3147 (1999),
Abstract;
Mechanism of inactivation of neuronal nitric oxide synthase by N-allyl-L-arginine: H.Q. Zhang, et al.; JACS 119, 10888 (1997),
Potent and selective inhibition of neuronal nitric oxide synthase by N-omega-propyl-L-arginine: H.Q. Zhang, et al.; J. Med. Chem.
40, 3869 (1997),
Abstract;
