Replaces Prod. #: BML-CN266
Potent neuronal nitric oxide synthase (nNOS; NOS I) inhibitor.
Product Details
| Alternative Name: | 1-(2-Trifluoromethylphenyl)imidazole |
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| Formula: | C10H7F3N2 |
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| MW: | 212.2 |
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| CAS: | 25371-96-4 |
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| Purity: | ≥98% (GC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (30mg/ml) or dichloromethane (25%); slightly soluble in water (5mg/ml), 0.1 N HCl (6mg/ml) or 0.1 N NaOH (2mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice: V. Volke, et al.; Behav. Brain Res.
140, 141 (2003),
Abstract;
Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitro indazole, after transient focal cerebral ischemia in the rat: K.J. Escott, et al.; J. Cereb. Blood Flow Metab.
18, 281 (1998),
Abstract;
Mechanism of the inhibition of neuronal nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM): R.L. Handy & P.K. Moore; Life Sci.
60, PL389 (1997),
Abstract;
Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects: R.L. Handy, et al.; Br. J. Pharmacol.
119, 423 (1996),
Abstract;
The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse: R.L. Handy, et al.; Br. J. Pharmacol.
116, 2349 (1995),
Abstract;
