Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

W-13 . hydrochloride

Calmodulin antagonist. PDE and MLCK inhibitor.
ALX-270-156-M005 5 mg 60.00 USD
Do you need bulk/larger quantities?
Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase.

Product Details

Alternative Name:N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide . HCl
Formula:C14H17ClN2O2S . HCl
MW:312.8 . 36.5
Purity:≥98% (TLC)
Identity:Determined by 1H-NMR and MS.
Appearance:White to beige solid.
Solubility:Soluble in water (warm) or methanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13: J.S. Stroble & V.A. Peterson; J. Pharm. Exp. Ther. 263, 186 (1992), Abstract;
Direct interaction of calmodulin antagonists with Ca2+/calmodulin- dependent cyclic nucleotide phosphodiesterase: H. Itoh & H. Hidaka; J. Biochem. 96, 1721 (1984), Abstract;
Calmodulin antagonists enhance calcium binding to calmodulin: M. Inagaki, et al.; Pharmacology 27, 125 (1983), Abstract;
Naphthalenesulfonamides as calmodulin antagonists: H. Hidaka & T. Tanaka; Meth. Enzymol. 102, 185 (1983), Abstract;
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives: H. Hidaka, et al.; Mol. Pharmacol. 20, 571 (1981), Abstract;
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]: H. Hidaka; Prot. Nucl. Acid Enz. 26, 977 (1981), Abstract;
Hydrophobic regions function in calmodulin-enzyme(s) interactions: T. Tanaka & H. Hidaka; J. Biol. Chem. 255, 11078 (1980), Abstract; Full Text