Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase.
Product Details
| Alternative Name: | N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide . HCl |
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| Formula: | C14H17ClN2O2S . HCl |
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| MW: | 312.8 . 36.5 |
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| Source: | Synthetic. |
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| CAS: | 88519-57-7 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | White to beige solid. |
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| Solubility: | Soluble in water (warm) or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13: J.S. Stroble & V.A. Peterson; J. Pharm. Exp. Ther.
263, 186 (1992),
Abstract;
Direct interaction of calmodulin antagonists with Ca2+/calmodulin- dependent cyclic nucleotide phosphodiesterase: H. Itoh & H. Hidaka; J. Biochem.
96, 1721 (1984),
Abstract;
Calmodulin antagonists enhance calcium binding to calmodulin: M. Inagaki, et al.; Pharmacology
27, 125 (1983),
Abstract;
Naphthalenesulfonamides as calmodulin antagonists: H. Hidaka & T. Tanaka; Meth. Enzymol.
102, 185 (1983),
Abstract;
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives: H. Hidaka, et al.; Mol. Pharmacol.
20, 571 (1981),
Abstract;
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]: H. Hidaka; Prot. Nucl. Acid Enz.
26, 977 (1981),
Abstract;
Hydrophobic regions function in calmodulin-enzyme(s) interactions: T. Tanaka & H. Hidaka; J. Biol. Chem.
255, 11078 (1980),
Abstract;
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