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ALX-270-111-M001 1 mg 48.00 USD
ALX-270-111-M005 5 mg 142.00 USD
ALX-270-111-M025 25 mg 552.00 USD
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Inhibitor of protein farnesylation in a cell free assay. Inhibits incorporation of tritiated mevalonate into proteins in whole cells. Mycotoxin with anti-bacterial, potassium uptake inhibitory and possibly carcinogenic activities. Known contaminant of spoiled apples.

Product Details

Alternative Name:4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one, Clairformin, Clavacin, Clavatin, Claviformin, Leucopin, Mycoin C3, Mycosin, Penicidin, Terinin
Source:Isolated from Penicillium expansum.
MI:14: 7053
Purity:≥98% (HPLC, TLC)
Appearance:White crystalline solid.
Solubility:Soluble in DMSO, methanol, ethanol or water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier: M. Goyer, et al.; PLoS One 11, e0149159 (2016), Application(s): Incubated into Caco-2 cells, Abstract; Full Text
Hplc detection of patulin in apple juice with GC/MS confirmation of patulin identity: J.A. Roach, et al.; Adv. Exp. Med. Biol. 504, 135 (2002), Review, Abstract;
Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin: E. Pfeiffer, et al.; Carcinogenesis 19, 1313 (1998), Abstract;
Inhibition of protein prenylation by patulin: S. Miura, et al.; FEBS Lett. 318, 88 (1993), Abstract;
Chronology of patulin-induced alterations in membrane function of cultured renal cells, LLC-PK: R.T. Riley, et al.; Toxicol. Appl. Pharmacol. 102, 128 (1990), Abstract;
Patulin: IARC Monographs 10, 205 (1976), Full Text
Effects of various lactones and related compounds on cation transfer in incubated cold-stored human erythrocytes: J.B. Kahn, Jr.; J. Pharmacol. Exp. Ther. 121, 234 (1957), Abstract;
Patulin in the common cold - Collaborative research on a derivative of Penicillium patulum bainier - II. Biochemistry and Chemistry: M. Birkinshaw, et al.; Lancet 245, 625 (1943), Abstract;