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Ophiobolin A

Calmodulin antagonist. PDE inhibitor.
 
ALX-270-109-M001 1 mg 310.00 USD
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Cell permeable antagonist of calmodulin. Inhibits Ca2+/calmodulin-dependent phosphodiesterase. Inhibits P-glycoprotein-mediated transport. Exhibits antibacterial, antitumor and nematocidal activities. Phytotoxic.

Product Details

Alternative Name:Cochliobolin A, Ophiobalin
 
Formula:C25H36O4
 
MW:400.6
 
Source:Isolated from Bipolaris leersia MST-FP107.
 
CAS:4611-05-6
 
RTECS:RL1576000
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 
ALX-270-109
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Product Literature References

Remodelling of Ca 2+ homeostasis is linked to enlarged endoplasmic reticulum in secretory cells: T. Pick, et al.; Cell Calcium 99, 102473 (2021), Abstract;
The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine: C. Chidley, et al.; eLife 5, e14601 (2016), Application(s): Reagent, used to assess cytotoxicity effects, Abstract; Full Text
Herbicidal potential of ophiobolins produced by Drechslera gigantea: A. Evidente, et al.; J. Agric. Food Chem. 54, 1779 (2006), Abstract;
Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products: N. Yoshida, et al.; Food Chem. Toxicol. 44, 2033 (2006), Abstract;
Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis: S. Quetglas, et al.; EMBO J. 21, 3970 (2002), Abstract; Full Text
The biology of ophiobolins: T.K. Au, et al.; Life Sci. 67, 733 (2000), Review, Abstract;
Microbial metabolites of ophiobolin A and antimicrobial evaluation of ophiobolins: E. Li, et al.; J. Nat. Prod. 58, 74 (1995), Abstract;
Characterization of the interaction of ophiobolin A and calmodulin: P.C. Leung, et al.; Int. J. Biochem. 20, 1351 (1988), Abstract;
Role of Calmodulin Inhibition in the Mode of Action of Ophiobolin A: P.C. Leung, et al.; Plant Physiol. 77, 303 (1985), Abstract; Full Text
Ophiobolin A. A natural product inhibitor of calmodulin: P.C. Leung, et al.; J. Biol. Chem. 259, 2742 (1984), Abstract; Full Text
The constitution of cochliobolin: L. Canonica, et al.; THL 7, 1211 (1966),
The structure of ophiobolin, a C25 terpenoid having a novel skeleton: S. Nozoe, et al.; JACS 87, 4968 (1965), Abstract;

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