Replaces Prod. #: BML-EI207
Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL). Protects cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death.
Product Details
Formula: | C13H9NOSe |
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MW: | 274.2 |
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CAS: | 60940-34-3 |
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Purity: | ≥98% (HPLC) |
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Identity: | Determined by NMR. |
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Appearance: | White to off-white crystalline solid. |
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Solubility: | Soluble in DMSO or 100% ethanol. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Handling: | Protect from light. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Differential induction of ATF3 and HO-1 in myeloid cells and keratinocytes via Dimethylfumarate or Cyclosporine A: S. Müller, et al.; J. Dermatol. Sci.
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Application(s): Treatment of human keratinocytes and PBMCs,
Abstract;
Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers: L. Zuo, et al.; J. Appl. Physiol.
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Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury: G. Tiegs, et al.; J. Pharmacol. Exp. Ther.
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Protection against peroxynitrite by selenoproteins: H. Sies, et al.; Z. Naturforsch. [C]
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Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals: N. Noguchi, et al.; Biochim. Biophys. Acta
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Action of ebselen as an antioxidant against lipid peroxidation:: N. Noguchi, et al.; Biochem. Pharmacol.
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Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51): M. Maiorino, et al.; Biochem. Pharmacol.
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Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions: M.J. Parnham & E. Graf; Biochem. Pharmacol.
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A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages: M.J. Parnham & S. Kindt; Biochem. Pharmacol.
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General Literature References
Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer: B. Kasraee, et al.; Exp. Dermatol.
21, 19 (2012),
Abstract;