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Organoselenium compound. Antioxidant.
ALX-270-097-M005 5 mg 40.00 USD
ALX-270-097-M025 25 mg 81.00 USD
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Replaces Prod. #: BML-EI207

Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL). Protects cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death.

Product Details

Purity:≥98% (HPLC)
Identity:Determined by NMR.
Appearance:White to off-white crystalline solid.
Solubility:Soluble in DMSO or 100% ethanol.
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

A general covalent binding model between cytotoxic selenocompounds and albumin revealed by mass spectrometry and X-ray absorption spectroscopy: W. Zheng, et al.; Sci. Rep. 10, 1274 (2020), Abstract; Full Text
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation: S. Hamarsheh, et al.; Nat. Commun. 11 , 1659 (2020), Abstract; Full Text
Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2: J.D. Bernstock, et al.; FASEB J. 32, 1677 (2018), Abstract;
Differential induction of ATF3 and HO-1 in myeloid cells and keratinocytes via Dimethylfumarate or Cyclosporine A: S. Müller, et al.; J. Dermatol. Sci. 87, 246 (2017), Application(s): Treatment of human keratinocytes and PBMCs, Abstract;
Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers: L. Zuo, et al.; J. Appl. Physiol. 111, 898 (2011), Abstract; Full Text
Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury: G. Tiegs, et al.; J. Pharmacol. Exp. Ther. 287, 1098 (1998), Abstract; Full Text
Protection against peroxynitrite by selenoproteins: H. Sies, et al.; Z. Naturforsch. [C] 53, 228 (1998), Abstract;
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite: H. Sies & H. Masumoto; Adv. Pharmacol. 38, 229 (1997), Abstract;
Free radical generation by selenium compounds and their prooxidant toxicity: J.E. Spallholz; Biomed. Environ. Sci. 10, 260 (1997), Abstract;
Ebselen: H. Sies; Meth. Enzymol. 252, 341 (1995), Abstract;
Molecular actions of ebselen-an antiinflammatory antioxidant: T. Schewe; Gen. Pharmacol. 26, 1153 (1995), Abstract;
Ebselen: a glutathione peroxidase mimic: H. Sies; Meth. Enzymol. 234, 476 (1994), Abstract;
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals: N. Noguchi, et al.; Biochim. Biophys. Acta 1213, 176 (1994), Abstract;
Interaction of ebselen with glutathione S-transferase and papain in vitro: T. Nikawa, et al.; Biochem. Pharmacol. 47, 1007 (1994), Abstract;
Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione: C. Schewe, et al.; Biochem. Pharmacol. 48, 65 (1994), Abstract;
Action of ebselen as an antioxidant against lipid peroxidation:: N. Noguchi, et al.; Biochem. Pharmacol. 44, 39 (1992), Abstract;
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?: I.A. Cotgreave, et al.; Biochem. Pharmacol. 38, 649 (1989), Abstract;
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51): M. Maiorino, et al.; Biochem. Pharmacol. 37, 2267 (1988), Abstract;
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions: M.J. Parnham & E. Graf; Biochem. Pharmacol. 36, 3095 (1987), Abstract;
A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages: M.J. Parnham & S. Kindt; Biochem. Pharmacol. 33, 3247 (1984), Abstract;

General Literature References

Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer: B. Kasraee, et al.; Exp. Dermatol. 21, 19 (2012), Abstract;

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