Selective inhibitor of protein kinase C (PKC). Enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
Product Details
| Alternative Name: | Ro 31-7549 . acetate |
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| Formula: | C24H22N4O2 . CH3COOH |
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| MW: | 398.5 . 60.1 |
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| CAS: | 138516-31-1 |
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| Purity: | ≥98% |
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| Appearance: | Red powder. |
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| Solubility: | Soluble in DMSO, methanol or water; slightly soluble in 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics
3, 490 (2004),
Abstract;
Full Text
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways: T. Ohtsuka & T. Zhou; J. Biol. Chem.
277, 29294 (2002),
Abstract;
Full Text
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases: T. Zhou, et al.; Nat. Med.
5, 42 (1999),
Abstract;
