Replaces Prod. #: BML-CN260
Potent cell-permeable inhibitor of nitric oxide synthase (NOS; IC50=82 nM in J774 cells). Ki’s using all human iNOS, eNOS and nNOS (19, 39 and 29 nM respectively) indicate doubtful selectivity.
Product Details
| Alternative Name: | S-Ethylisothiourea . HBr, 2-Ethyl-2-thiopseudourea . HBr |
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| Formula: | C3H9NSBr |
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| MW: | 185.1 |
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| CAS: | 1071-37-0 |
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| RTECS: | UM6825000 |
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| Purity: | ≥97% |
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| Appearance: | White powder. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity: G.J. Southan, et al.; Br. J. Pharmacol.
114, 510 (1995),
Abstract;
Novel potent and selective inhibitors of inducible nitric oxide synthase: M. Nakane, et al.; Mol. Pharmacol.
47, 831 (1995),
Abstract;
Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas: E.P. Garvey, et al.; J. Biol. Chem.
269, 26669 (1994),
Abstract;
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