The proteolytic activity of the paracaspase MALT1 is key to NF-κB and T cell activation. Z-VRPR-FMK is a selective MALT1 inhibitor of such proteolytic activity.
Product Details
| Alternative Name: | Z-Val-Arg-Pro-DL-Arg-FMK, MALT1 inhibitor |
| |
| Sequence: | Z-Val-Arg-Pro-DL-Arg-fluoromethylketone . TFA |
| |
| Formula: | C31H49FN10O6 |
| |
| MW: | 676.8 |
| |
| Purity: | ≥90% (HPLC) |
| |
| Appearance: | White to slightly yellow powder. |
| |
| Solubility: | Soluble in water (1mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | Hygroscopic. Avoid freeze/thaw cycles. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells: H. Yin, et al.; Cell. Mol. Life Sci.
112, 709 (2022),
Abstract;
Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles: G. Camilli, et al.; Eur. J. Immunol.
48, 757 (2018),
Abstract;
Full Text
MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression: D. Pan, et al.; Oncogene
35, 919 (2016),
Application(s): Cell Culture,
Abstract;
MALT 1 Protease Activity Is Required for Innate and Adaptive Immune Responses: J.W. Yu, et al.; PLoS One
10, e0127083 (2015),
Abstract;
Full Text
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling: T. Klein, et al.; Nat. Commun.
6, 8777 (2015),
Application(s): Primary hematopoietic cell culture,
Abstract;
Full Text
Coregulation and modulation of NFκB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation: N. Fernandez-Jimenez, et al.; Hum. Mol. Genet.
23, 1298 (2014),
Application(s): Assay,
Abstract;
Full Text
Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms: Y. Yang, et al.; Cancer Discov.
4, 480 (2014),
Abstract;
Full Text
Measurement of Endogenous MALT1 Activity: D. Nagel, et al.; Bio-protocol
3, 1 (2013),
Full Text
Mechanism and specificity of the human paracaspase MALT1: J. Hachmann, et al.; Biochem. J.
443, 287 (2012),
Application(s): Titration,
Abstract;
Full Text
The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol.
9, 272 (2008),
Abstract;
