Selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Protects neurotoxin-insulted neurons from apoptotic death. Displays minimal in vivo toxicity. To reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated.
Product Details
| Alternative Name: | pan-Caspase inhibitor (fluoromethylketone), N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone |
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| Formula: | C26H25F2N3O6 |
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| MW: | 513.8 |
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| Purity: | ≥90% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (10mM). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Keep under inert gas. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells: D. Moujalled, et al.; Cell Death Differ.
29, 1335 (2022),
Abstract;
Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells: R. Ryan, et al.; BMC Microbiol.
11, 237 (2011),
Application(s): WB of human dendritic cells,
Abstract;
Full Text
Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia: K. Patil & S.C. Sharma; Neuroreport
15, 981 (2004),
Abstract;
Caspase inhibition switches doxorubicin-induced apoptosis to senescence: A. Rebbaa, et al.; Oncogene
22, 2805 (2003),
Abstract;
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis
8, 345 (2003),
Abstract;
