Selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Protects neurotoxin-insulted neurons from apoptotic death. Displays minimal in vivo toxicity. To reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated.
Product Details
| Alternative Name: | pan-Caspase inhibitor (fluoromethylketone), N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone |
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| Formula: | C26H25F2N3O6 |
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| MW: | 513.8 |
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| Purity: | ≥90% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (10mM). |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Keep under inert gas. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells: R. Ryan, et al.; BMC Microbiol.
11, 237 (2011),
Application(s): WB of human dendritic cells,
Abstract;
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Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia: K. Patil & S.C. Sharma; Neuroreport
15, 981 (2004),
Abstract;
Caspase inhibition switches doxorubicin-induced apoptosis to senescence: A. Rebbaa, et al.; Oncogene
22, 2805 (2003),
Abstract;
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis
8, 345 (2003),
Abstract;
