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Z-YVAD-FMK (Ready-to-Use)

Inhibitor of caspase-1 and -4
 
ALX-260-154-R100 100 µl 2mM 200.00 USD
 
ALX-260-154-R020 20 µl 10mM 200.00 USD
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Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.

Product Specification

Alternative Name:Caspase-1 inhibitor (fluoromethylketone)
 
Sequence:Z-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone
 
MW:630.7
 
Source:Synthetic.
 
Formulation:Liquid. In DMSO.
 
Purity:≥99% (HPLC)
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:We recommend a final concentration of 2-10µM for inhibiting caspase-1 activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Inflammasome-Driven Interleukin-1α andInterleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity: X. Jiang, et al.; JACC Basic Transl. Sci. 4, 304 (2019), Abstract; Full Text
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation: C. Zhang, et al.; J. Clin. Invest. 128, 5399 (2018), Abstract; Full Text
Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells: V. Klöss, et al.; Front. Immunol. 8, 1238 (2017), Abstract; Full Text
Rickettsia australis Activates Inflammasome in Human and Murine Macrophages: C. Smalley, et al.; PLoS One 11, e0157231 (2016), Application(s): Caspase-1 inhibition, Abstract; Full Text
Inflammasome Activation Contributes to Interleukin-23 Production in Response to Clostridium difficile: C. A. Cowardin, et al.; MBio. 6, e02386-14 (2015), Application(s): Cell Culture, Abstract; Full Text
The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction: L. Mortimer, et al.; PLoS Pathog. 11, e1004887 (2015), Abstract; Full Text

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