Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10. The inhibitor is designed as a methyl ester to facilitate cell permeability.
Product Details
| Alternative Name: | Caspase-8 inhibitor (fluoromethylketone), Granzyme B inhibitor (fluoromethylketone) |
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| Sequence: | Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone |
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| MW: | 654.0 |
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| Formulation: | Liquid. In DMSO. |
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| Purity: | ≥99% (HPLC) |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells: V. Klöss, et al.; Front. Immunol.
8, 1238 (2017),
Abstract;
Full Text
Dasatinib promotes paclitaxel-induced necroptosis in lung adenocarcinoma with phosphorylated caspase-8 by c-Src: Y. Diao, et al.; Cancer Lett.
379, 12 (2016),
Application(s): Cell culture,
Abstract;
Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB: M. Oliver Metzig, et al.; Oncogene
35, 3399 (2016),
Application(s): Cell culture ,
Abstract;
Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6: S. Schüll, et al.; Cell Death Dis.
6, e1691 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death: A.L. Mahul-Mellier, et al.; Cell Death Differ.
22, 2107 (2015),
Application(s): Cell Culture,
Abstract;
Guggulsterone inhibits human cholangiocarcinoma Sk-ChA-1 and Mz-ChA-1 cell growth by inducing caspase-dependent apoptosis and downregulation of survivin and Bcl-2 expression: F. Zhong, et al.; Oncol. Lett.
10, 1416 (2015),
Application(s): Cell Culture,
Abstract;
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