Irreversible, cell permeable inhibitor of caspase-3 and -7.
Product Details
| Alternative Name: | Caspase-3 inhibitor (fluoromethylketone), Caspase-7 inhibitor (fluoromethylketone) |
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| Sequence: | Z-Asp-Glu-Val-Asp-fluoromethylketone |
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| MW: | 668.0 |
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| Formulation: | Liquid. In DMSO. |
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| Purity: | ≥98% (HPLC) |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Apoptosis was induced in Jurkat cells with camptothecin in the presence of various concentrations (0-3μM) of Z-DEVD-FMK (Ready-to-Use) (Prod. No.
ALX-260-141) as indicated. Caspase activity was analyzed using Caspase-3 Fluorometric Assay Kit (Prod. No.
ALX-850-216)."
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Product Literature References
Conjunctival epitheliopathy induced by topical exposure to bacterial peptidoglycan, muramyl dipeptide: M.P. Langford, et al.; Exp. Eye Res.
227, 109383 (2023),
Abstract;
Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B: K. Fettucciari, et al.; Cell. Mol. Life Sci.
79, 442 (2022),
Abstract;
Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling: L.E. Araya, et al.; ACS Chem. Biol.
16, 2280 (2021),
Abstract;
Coordination of receptor tyrosine kinase signaling and interfacial tension dynamics drive radial intercalation and tube elongation: N. Neumann, et al.; Dev. Cell
45, 67 (2018),
Abstract;
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