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Z-DEVD-FMK (Ready-to-Use)

Inhibitor of caspase-3 and -7
ALX-260-141-R100 100 µl 2mM 243.00 USD
ALX-260-141-R020 20 µl 10mM 243.00 USD
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Irreversible, cell permeable inhibitor of caspase-3 and -7.

Product Details

Alternative Name:Caspase-3 inhibitor (fluoromethylketone), Caspase-7 inhibitor (fluoromethylketone)
Formulation:Liquid. In DMSO.
Purity:≥98% (HPLC)
Shipping:Blue Ice
Long Term Storage:-20°C
Technical Info/Product Notes:We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
Regulatory Status:RUO - Research Use Only
Z-DEVD-FMK (Ready-to-Use) image
Figure: Apoptosis was induced in Jurkat cells with camptothecin in the presence of various concentrations (0-3μM) of Z-DEVD-FMK (Ready-to-Use) (Prod. No. ALX-260-141) as indicated. Caspase activity was analyzed using Caspase-3 Fluorometric Assay Kit (Prod. No. ALX-850-216)."
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Z-DEVD-FMK (Ready-to-Use) image

Product Literature References

Conjunctival epitheliopathy induced by topical exposure to bacterial peptidoglycan, muramyl dipeptide: M.P. Langford, et al.; Exp. Eye Res. 227, 109383 (2023), Abstract;
Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B: K. Fettucciari, et al.; Cell. Mol. Life Sci. 79, 442 (2022), Abstract;
Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling: L.E. Araya, et al.; ACS Chem. Biol. 16, 2280 (2021), Abstract;
Coordination of receptor tyrosine kinase signaling and interfacial tension dynamics drive radial intercalation and tube elongation: N. Neumann, et al.; Dev. Cell 45, 67 (2018), Abstract; Full Text

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