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Substrate for caspase-1, -4-, -5 and -14
ALX-260-117-M005 5 mg 256.00 USD
ALX-260-117-M010 10 mg 484.00 USD
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Fluorogenic substrate for caspase-1, -4, -5 and -14.

Product Details

Alternative Name:Caspase-1 substrate (fluorogenic), Caspase-5 substrate (fluorogenic)
Sequence:Ac-Trp-Glu-His-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
Peptide Content:70-90%
Purity:≥98% (HPLC)
Appearance:White to yellow powder.
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Solution in DMSO is stable for 6-8 months when stored at -20°C.
Handling:Keep cool and dry.
Technical Info/Product Notes:AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
Regulatory Status:RUO - Research Use Only

Product Literature References

Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold: B.B. Verdugo, et al.; J. Biol. Chem. 298, 101931 (2022), Abstract;
Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome: R.V.H. De Carvalho, et al.; Cell Rep. 26, 429 (2019), Abstract;
Noninvasive evaluation of the chronic influence of local air velocity from an air conditioner using salivary cortisol and skin caspase-14 as biomarkers of psychosomatic and environmental stress: M. Yamaguchi, et al.; J. Int. Med. Res. 40, 1429 (2012), Abstract;