Fluorogenic substrate for caspase-1 and -4.
Product Details
| Alternative Name: | Caspase-1 substrate (fluorogenic), Caspase-4 substrate (fluorogenic) |
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| Sequence: | Ac-Tyr-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin) |
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| Formula: | C33H36F3N5O10 |
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| MW: | 719.7 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solid product is stable for 1 year in desiccator when stored at room temperature. Stock solutions are stable for 6 – 8 months when stored at –20°C. Keep sealed after removing from the freezer until its temperature equilibrates with room temperature. |
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| Handling: | Keep cool and dry. |
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| Technical Info/Product Notes: | AFC has an excitation maximum of 400nm and an emission maximum of 505nm. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout: S. Devi, et al.; Cell Rep.
42, 112265 (2023),
Abstract;
TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells: M. Furuoka, et al.; J. Cell. Physiol.
231, 2761 (2016),
Abstract;
Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP: M. Marcelli, et al.; Cancer Res.
58, 76 (1998),
Abstract;
