Replaces Prod. #: BML-ZW8445
Potent, reversible proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Has been shown to induce apoptosis in Rat-1 and PC12 cells via a p53-dependent pathway.The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-115 activates autophagy.
Product Details
| Alternative Name: | Z-LL-Nva-CHO, Z-Leu-Leu-Nva-CHO |
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| Sequence: | Z-Leu-Leu-Nva-CHO |
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| Formula: | C25H39N3O5 |
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| MW: | 461.6 |
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| CAS: | 133407-86-0 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9: J. Won Yoon, et al.; DNA Repair (Amst.)
34, 9 (2015),
Application(s): Western Blot,
Abstract;
Ras is involved in the negative control of autophagy through the class I PI3-kinase: S. Furuta, et al.; Oncogene
23, 3898 (2004),
Abstract;
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression: L. Salmena, et al.; Biochem. Pharmacol.
61, 795 (2001),
Abstract;
Proteasome inhibition results in increased poly-ADP-ribosylation: implications for neuron death: J.N. Keller & W.R. Markesbery; J. Neurosci. Res.
61, 436 (2000),
Abstract;
p53-dependent induction of apoptosis by proteasome inhibitors: U.G. Lopes, et al.; J. Biol. Chem.
272, 12893 (1997),
Abstract;
Full Text
Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae: D.H. Lee & A.L. Goldberg; J. Biol. Chem.
271, 27280 (1996),
Abstract;
Full Text
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules: K.L. Rock, et al.; Cell
78, 761 (1994),
Abstract;
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B: V.J. Palombella, et al.; Cell
78, 773 (1994),
Abstract;
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex: A. Vinitsky, et al.; Biochemistry
31, 9421 (1992),
Abstract;
General Literature References
The structure-function relationship between peptide aldehyde derivatives on initiation of neurite outgrowth in PC12h cells: Y. Saito, et al.; Neurosci. Lett.
120, 1 (1990),
Abstract;
