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Proteasome inhibitor I (aldehyde)

ALX-260-089-M001 1 mg 182.00 USD
ALX-260-089-M005 5 mg 382.00 USD
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Replaces Prod. #: BML-ZW8410

Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid (Prod. No. ALX-350-003) through inhibition of IκBα degradation.

Product Details

Alternative Name:Z-IE(OtBu)AL-CHO, Z-Ile-Glu(OtBu)-Ala-Leu-CHO, PSI
Purity:≥95% (TLC)
Appearance:White powder.
Solubility:Soluble in 100% ethanol (30mg/ml), DMSO (30mg/ml) or methanol (50mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B: J.M. Griscavage, et al.; PNAS 93, 3308 (1996), Abstract; Full Text
Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway: S. Mori, et al.; J. Biol. Chem. 270, 29447 (1995), Abstract; Full Text
A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin- protein conjugates in a neuronal cell: M.E. Figueiredo-Pereira, et al.; J. Neurochem. 63, 1578 (1994), Abstract;
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B: E.B. Traenckner, et al.; EMBO J. 13, 5433 (1994), Abstract;

Related Products

Okadaic acid (high purity) 

Inhibitor of PP1 and PP2A
78111-17-8, Isolated from Prorocentrum Sp., ≥98% (HPLC, TLC) | Print as PDF
ALX-350-003-C025 25 µg 106.00 USD
ALX-350-003-C050 50 µg 194.00 USD
ALX-350-003-C100 100 µg 262.00 USD
ALX-350-003-M001 1 mg 1,783.00 USD
Do you need bulk/larger quantities?

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