Replaces Prod. #: BML-ZW8410
Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid (Prod. No. ALX-350-003) through inhibition of IκBα degradation.
Product Details
| Alternative Name: | Z-IE(OtBu)AL-CHO, Z-Ile-Glu(OtBu)-Ala-Leu-CHO, PSI |
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| Sequence: | Z-Ile-Glu(OtBu)-Ala-Leu-CHO |
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| Formula: | C32H50N4O8 |
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| MW: | 618.8 |
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| Purity: | ≥95% (TLC) |
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| Appearance: | White powder. |
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| Solubility: | Soluble in 100% ethanol (30mg/ml), DMSO (30mg/ml) or methanol (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B: J.M. Griscavage, et al.; PNAS
93, 3308 (1996),
Abstract;
Full Text
Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway: S. Mori, et al.; J. Biol. Chem.
270, 29447 (1995),
Abstract;
Full Text
A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin- protein conjugates in a neuronal cell: M.E. Figueiredo-Pereira, et al.; J. Neurochem.
63, 1578 (1994),
Abstract;
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B: E.B. Traenckner, et al.; EMBO J.
13, 5433 (1994),
Abstract;
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