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Caspase-9 substrate
ALX-260-080-M001 1 mg 65.00 USD
ALX-260-080-M005 5 mg 194.00 USD
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Replaces Prod. #: BML-P444

Fluorogenic substrate for caspase-9 and related cysteine proteases. The LEHD sequence is derived from combinatorial experiments. Ex.:340-360nm, Em.:440-460nm.

Product Details

Alternative Name:Caspase-9 substrate (fluorogenic)
Sequence:Ac-Leu-Glu-His-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
Peptide Content:75-95%
Purity:≥98% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in water,  DMSO or phosphate buffer, pH 7.5.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Keep cool and dry.
Technical Info/Product Notes:AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.
Regulatory Status:RUO - Research Use Only

Product Literature References

Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells: D. Bloemberg & J. Quadilatero; J. Cell. Physiol. 236, 3099 (2021), Application(s): Caspase-9 activity assay on cell lysates, Abstract;
Study of commonly used organophosphate pesticides that induced oxidative stress and apoptosis in peripheral blood lymphocytes of rats: A. Ojha, et al.; Hum. Exp. Toxicol. 36, 1158 (2017), Abstract;
The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging: K. Vorobej, et al.; Exp. Gerontol. 101, 69 (2017), Abstract;
Data on skeletal muscle apoptosis, autophagy, and morphology in mice treated with doxorubicin: T.L. Campbell, et al.; Data Brief 7, 786 (2016), Application(s): Assessed caspase-3, -8, and -9 activity in mixed gastrocnemius homogenates, Abstract;
Protolichesterinic acid enhances doxorubicin-induced apoptosis in HeLa cells in vitro: F. Brisdelli, et al.; Life Sci. 158, 89 (2016), Application(s): Caspase activity, Abstract;
Ruthenium Complexes Induce HepG2 Human Hepatocellular Carcinoma Cell Apoptosis and Inhibit Cell Migration and Invasion through Regulation of the Nrf2 Pathway: Y. Lu, et al.; Int. J. Mol. Sci. 17, E775 (2016), Application(s): Caspase activation by Ru complexes, Abstract; Full Text
Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing: C. Lawlor, et al.; PLoS One 11, e0149167 (2016), Application(s): Caspase activity assays, Abstract; Full Text
Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles: E.M. McMillan, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R531 (2011), Abstract; Full Text
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells: J. Hofmanova; Eur. J. Nutrition 44, 40 (2005), Abstract;
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004), Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;

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