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United States 


Inhibitor of caspase-6, -8 and -10
ALX-260-062-M001 1 mg 136.00 USD
ALX-260-062-M005 5 mg 534.00 USD
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Replaces Prod. #: BML-P440

Reversible aldehyde inhibitor of caspase-6. Also inhibits caspase-8 and -10. Sequence is based on lamin A site of cleavage.

Product Details

Alternative Name:Caspase-6 inhibitor (aldehyde)
Peptide Content:70-90%.
Purity:≥95% (HPLC)
Appearance:White powder.
Solubility:Soluble in DMSO or water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stock solutions should be divided into aliquots and stored at -20°C. The solution is stable for weeks when stored at -20°C and protected from light. Do not dissolve in aqueous buffer due to possible racemization.
Handling:Keep cool and dry.
Regulatory Status:RUO - Research Use Only

Product Literature References

Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-7: E.S. Okerberg, et al.; Biochemistry 58, 5320 (2019), Abstract;
Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding: K.B. Dagbay, et al.; J. Biol. Chem. 292, 4885 (2017), Abstract; Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;
Substrate specificities of caspase family proteases: R.V. Talanian et al.; J. Biol. Chem. 272, 9677 (1997), Abstract;
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32: S.M. Srinivasula et al.; J. Biol. Chem. 271, 27099 (1996), Abstract;