Replaces Prod. #: BML-P462
Fluorogenic substrate for caspase-2. Preferred cleavage site for caspase-2 (Km=80μM).
Product Details
| Alternative Name: | Caspase-2 substrate (fluorogenic) |
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| Sequence: | Ac-Val-Asp-Val-Ala-Asp-AMC (AMC=7-Amino-4-methylcoumarin) |
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| Formula: | C33H44N6O12 |
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| MW: | 716.8 |
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| Peptide Content: | 75-95% |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO (100mM). Dilute with distilled water or buffer, pH 7.0-7.5 (e. g. TRIS, HEPES). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Keep cool and dry. |
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| Technical Info/Product Notes: | AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging: K. Vorobej, et al.; Exp. Gerontol.
101, 69 (2017),
Abstract;
Effect of mitochondrial fission inhibition on C2C12 differentiation: D. Bloemberg, et al.; Data Brief
7, 634 (2016),
Application(s): Caspase activity,
Abstract;
Full Text
CD 95-independent mechanisms of IL-2 deprivation-induced apoptosis in activated human lymphocytes: T. Hieronymus, et al.; Cell Death Differ.
7, 538 (2000),
Abstract;
Substrate specificities of caspase family proteases: R.V. Talanian, et al.; J. Biol. Chem.
272, 9677 (1997),
Abstract;
Full Text
