Reversible, cell permeable inhibitor of caspase-1 and -5. Also inhibits caspase-4 and -14.
Product Details
| Alternative Name: | Caspase-1 inhibitor (aldehyde), Caspase-5 inhibitor (aldehyde) |
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| Sequence: | Ac-Trp-Glu-His-Asp-CHO |
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| Formula: | C28H33N7O9 |
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| MW: | 611.6 |
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| Formulation: | TFA salt. |
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| Purity: | ≥90% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solution is stable for 1 month when stored at -20°C and protected from light. |
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| Handling: | Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps: G. Sollberger, et al.; Sci. Immunol.
3, eaar6689 (2018),
Abstract;
Design and application of a fluorogenic assay for monitoring inflammatory caspase activity: R. Ranganathan, et al.; Anal. Biochem.
543, 1 (2017),
Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem.
272, 17907 (1997),
Abstract;
Full Text
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE): T.A. Rano, et al.; Chem. Biol.
4, 149 (1997),
Abstract;
