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United States 


Inhibitor of caspase-1, -4, -5 and -14.
ALX-260-055-M001 1 mg 155.00 USD
ALX-260-055-M005 5 mg 578.00 USD
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Reversible, cell permeable inhibitor of caspase-1 and -5. Also inhibits caspase-4 and -14.

Product Details

Alternative Name:Caspase-1 inhibitor (aldehyde), Caspase-5 inhibitor (aldehyde)
Formulation:TFA salt.
Purity:≥90% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in water (10mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Solution is stable for 1 month when stored at -20°C and protected from light.
Handling:Keep cool and dry.
Regulatory Status:RUO - Research Use Only

Product Literature References

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps: G. Sollberger, et al.; Sci. Immunol. 3, eaar6689 (2018), Abstract;
Design and application of a fluorogenic assay for monitoring inflammatory caspase activity: R. Ranganathan, et al.; Anal. Biochem. 543, 1 (2017), Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract; Full Text
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE): T.A. Rano, et al.; Chem. Biol. 4, 149 (1997), Abstract;