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Protease substrate
ALX-260-054-M005 5 mg 46.00 USD
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Replaces Prod. #: BML-P130

Substrate for porcine calpain I and II. Also cleaved by papain and E. coli protease Ti. Ex.: 340-360nm, Em.: 440-460nm. This substrate is useful for inhibitor screening and kinetic analysis.

Product Details

Alternative Name:Suc-LY-AMC
Sequence:Suc-Leu-Tyr-AMC (AMC=7-Amino-4-methylcoumarin)
Appearance:White to off-white powder.
Solubility:Soluble in 80% acetic acid, DMSO or methanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells: B. Del Bello, et al.; PLoS One 8, e57236 (2013), Abstract; Full Text
Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus: I.O. Donkor & M.L. Sanders; Bioorg. Med. Chem. Lett. 11, 2647 (2001), Abstract;
Na+, K+-specific inhibition of protein and peptide hydrolyses by proteasomes from human hepatoma tissues: J.H. Seol, et al.; FEBS Lett. 247, 197 (1989), Abstract;
Protease Ti from Escherichia coli requires ATP hydrolysis for protein breakdown but not for hydrolysis of small peptides: K.M. Woo, et al.; J. Biol. Chem. 264, 2088 (1989), Abstract; Full Text
Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates: T. Sasaki, et al.; J. Biol. Chem. 259, 12489 (1984), Abstract;