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Caspase substrate
ALX-260-048-M001 1 mg 73.00 USD
ALX-260-048-M005 5 mg 109.00 USD
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Replaces Prod. #: BML-P435

Chromogenic substrate for caspase-3 with increased cell permeability. Also substrate for caspase-1, -4 and -7. λmax of pNA is 400nm. Similar to Ac-DEVD-pNA except the N-terminus is blocked by a benzyloxycarbonyl (Z) moiety which may increase cell permeability.

Product Details

Alternative Name:Caspase-3 substrate (chromogenic)
Sequence:Z-Asp-Glu-Val-Asp-pNa (pNA = p-Nitroaniline)
Peptide Content:70-90%
Purity:≥99% (HPLC)
Appearance:White powder.
Solubility:Soluble in DMSO or acetonitrile.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Keep cool and dry.
Regulatory Status:RUO - Research Use Only

Product Literature References

Propeptide-mediated inhibition of cognate gingipain proteinases: N.L. Hug, et al.; PLoS One 8, e65447 (2013), Abstract; Full Text
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis: R. Datta, et al.; J. Biol. Chem. 272, 1965 (1997), Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract;
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature 371, 346 (1994), Abstract;
Interleukin-1 beta converting enzyme: N.A. Thornberry; Methods Enzymol. 244, 615 (1994), Abstract;