Replaces Prod. #: BML-P435
Chromogenic substrate for caspase-3 with increased cell permeability. Also substrate for caspase-1, -4 and -7. λmax of pNA is 400nm. Similar to Ac-DEVD-pNA except the N-terminus is blocked by a benzyloxycarbonyl (Z) moiety which may increase cell permeability.
Product Details
| Alternative Name: | Caspase-3 substrate (chromogenic) |
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| Sequence: | Z-Asp-Glu-Val-Asp-pNa (pNA = p-Nitroaniline) |
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| Formula: | C32H38N6O14 |
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| MW: | 730.7 |
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| Formulation: | Lyophilized. |
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| Peptide Content: | 70-90% |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White powder. |
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| Solubility: | Soluble in DMSO or acetonitrile. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Propeptide-mediated inhibition of cognate gingipain proteinases: N.L. Hug, et al.; PLoS One
8, e65447 (2013),
Abstract;
Full Text
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis: R. Datta, et al.; J. Biol. Chem.
272, 1965 (1997),
Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature
376, 37 (1995),
Abstract;
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature
371, 346 (1994),
Abstract;
Interleukin-1 beta converting enzyme: N.A. Thornberry; Methods Enzymol.
244, 615 (1994),
Abstract;
