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Caspase inhibitor
ALX-260-046-M001 1 mg 113.00 USD
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Replaces Prod. #: BML-P414

Reversible, cell permeable inhibitor of caspase-3. Also inhibits caspase-6, -7, -8 and -10.

Product Details

Alternative Name:Caspase-3 inhibitor (aldehyde)
Formulation:Lyophilized. TFA salt.
Peptide Content:65-95%.
Purity:≥95% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:After dissolving, prepare aliquots and store at -20°C. Keep cool and dry.
Regulatory Status:RUO - Research Use Only

Product Literature References

Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity: S.C. Wright, et al.; J. Exp. Med. 186, 1107 (1997), Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: W. Nicholson, et al.; Nature 376, 37 (1995), Abstract;
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase: M. Tewari, et al.; Cell 81, 801 (1995), Abstract;