Replaces Prod. #: BML-P414
Reversible, cell permeable inhibitor of caspase-3. Also inhibits caspase-6, -7, -8 and -10.
Product Details
| Alternative Name: | Caspase-3 inhibitor (aldehyde) |
| |
| Sequence: | Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO |
| |
| Formula: | C94H158N20O27 |
| |
| MW: | 2000.4 |
| |
| Formulation: | Lyophilized. TFA salt. |
| |
| Peptide Content: | 65-95%. |
| |
| Purity: | ≥95% (HPLC) |
| |
| Appearance: | White to off-white powder. |
| |
| Solubility: | Soluble in DMSO. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | After dissolving, prepare aliquots and store at -20°C. Keep cool and dry. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity: S.C. Wright, et al.; J. Exp. Med.
186, 1107 (1997),
Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: W. Nicholson, et al.; Nature
376, 37 (1995),
Abstract;
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase: M. Tewari, et al.; Cell
81, 801 (1995),
Abstract;
