Replaces Prod. #: BML-P430
Reversible inhibitor of caspase-6, -8 and granzyme B. Also inhibits caspase-10.
Product Details
| Alternative Name: | Caspase-8 inhibitor (aldehyde), Granzyme B inhibitor (aldehyde) |
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| Sequence: | Ac-Ile-Glu-Thr-Asp-CHO |
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| Formula: | C21H34N4O10 |
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| MW: | 502.5 |
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| CAS: | 191338-86-0 |
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| Formulation: | Lyophilized. |
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| Peptide Content: | 70-90% |
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| Purity: | ≥96% (HPLC) |
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| Solubility: | Soluble in distilled water at 10 mg/mL and in DMSO at 1 mg/mL. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Use always fresh solutions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem.
273, 32608 (1998),
Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem.
272, 17907 (1997),
Abstract;
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem.
272, 13432 (1997),
Abstract;
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