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Caspase and granzyme inhibitor
ALX-260-043-M001 1 mg 99.00 USD
ALX-260-043-M005 5 mg 398.00 USD
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Replaces Prod. #: BML-P430

Reversible inhibitor of caspase-6, -8 and granzyme B. Also inhibits caspase-10.

Product Details

Alternative Name:Caspase-8 inhibitor (aldehyde), Granzyme B inhibitor (aldehyde)
Peptide Content:70-90%
Purity:≥96% (HPLC)
Solubility:Soluble in distilled water at 10 mg/mL and in DMSO at 1 mg/mL.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Use always fresh solutions.
Regulatory Status:RUO - Research Use Only

Product Literature References

Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998), Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997), Abstract; Full Text