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Caspase and granzyme substrate
ALX-260-042-M001 1 mg 60.00 USD
ALX-260-042-M005 5 mg 201.00 USD
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Replaces Prod. #: BML-P432

Fluorogenic substrate for caspase-6 and -8 and granzyme B. Also a substrate for caspase-10.

Product Details

Alternative Name:Granzyme B substrate (fluorogenic), Caspase-8 substrate (fluorogenic)
Sequence:Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
Peptide Content:70-90%
Purity:≥97% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in DMSO. Dilute with buffer, pH 7.5.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light. Keep cool and dry.
Technical Info/Product Notes:AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.
Regulatory Status:RUO - Research Use Only

Product Literature References

Involvement of Bid in the crosstalk between ferroptotic agent-induced ER stress and TRAIL-induced apoptosis: J.H. Kim, et al.; J. Cell. Physiol. 237, 4180 (2022), Abstract;
C33-A cells transfected with E6*I or E6*II the short forms of HPV-16 E6, displayed opposite effects on cisplatin-induced apoptosis: C.E. Vaisman, et al.; Virus Res. 247, 94 (2018), Abstract;
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC8: N. Van Opdenbosch, et al.; Cell Rep. 21, 3427 (2017), Abstract; Full Text
The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging: K. Vorobej, et al.; Exp. Gerontol. 101, 69 (2017), Abstract;
Ruthenium Complexes Induce HepG2 Human Hepatocellular Carcinoma Cell Apoptosis and Inhibit Cell Migration and Invasion through Regulation of the Nrf2 Pathway: Y. Lu, et al.; Int. J. Mol. Sci. 17, E775 (2016), Application(s): Caspase activation by Ru complexes, Abstract; Full Text
Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing: C. Lawlor, et al.; PLoS One 11, e0149167 (2016), Application(s): Caspase activity assays, Abstract; Full Text
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004), Abstract;
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis: R. Datta, et al.; J. Biol. Chem. 272, 1965 (1997), Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract;
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature 371, 346 (1994), Abstract;
Interleukin-1 beta converting enzyme: N.A. Thornberry; Methods Enzymol. 244, 615 (1994), Abstract;