Inhibitor of dipeptidyl aminopeptidase IV.
Product Details
| Alternative Name: | H-Ile-Pro-Ile-OH |
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| Formula: | C17H31N3O4 |
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| MW: | 341.5 |
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| Source: | Synthetic. |
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| CAS: | 90614-48-5 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Application Notes: | May be used to inhibit GLP-1 breakdown in blood, plasma and serum samples at a concentration of 100 µM. |
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| Solubility: | Soluble in water (1mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The postprandial secretion of peptide YY1-36 and 3-36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy: A.M. Kowalka, et al.; Clin. Endocrinol.
99, 272 (2023),
Abstract;
Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling: M. Capitano, et al.; J. Clin. Invest.
129, 2555 (2019),
Abstract;
Full Text
Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig: C.F. Deacon, et al.; Diabetes
47, 764 (1998),
Abstract;
Full Text
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum: R. Mentlein, et al.; Eur. J. Biochem.
214, 829 (1993),
Abstract;
Full Text
Murine thymocytes possess specific cell surface-associated exoaminopeptidase activities: preferential expression by immature CD4- CD8- subpopulation: B. Bauvois; Eur. J. Immunol.
20, 459 (1990),
Abstract;
Purification and some properties of a membrane-bound dipeptidyl peptidase IV of guinea pig casein-induced intraperitoneal leukocytes: M. Kudo, et al.; J. Biochem.
97, 1211 (1985),
Abstract;
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria: H. Umezawa, et al.; J. Antibiot.
37, 422 (1984),
Abstract;
