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Diprotin A

DPP4 inhibitor
ALX-260-036-M005 5 mg 55.00 USD
ALX-260-036-M025 25 mg 91.00 USD
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Inhibitor of dipeptidyl aminopeptidase IV.

Product Details

Alternative Name:H-Ile-Pro-Ile-OH
Purity:≥98% (HPLC)
Appearance:White to off-white solid.
Application Notes:May be used to inhibit GLP-1 breakdown in blood, plasma and serum samples at a concentration of 100 µM.
Solubility:Soluble in water (1mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

The postprandial secretion of peptide YY1-36 and 3-36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy: A.M. Kowalka, et al.; Clin. Endocrinol. 99, 272 (2023), Abstract;
Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling: M. Capitano, et al.; J. Clin. Invest. 129, 2555 (2019), Abstract; Full Text
Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig: C.F. Deacon, et al.; Diabetes 47, 764 (1998), Abstract; Full Text
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum: R. Mentlein, et al.; Eur. J. Biochem. 214, 829 (1993), Abstract; Full Text
Murine thymocytes possess specific cell surface-associated exoaminopeptidase activities: preferential expression by immature CD4- CD8- subpopulation: B. Bauvois; Eur. J. Immunol. 20, 459 (1990), Abstract;
Purification and some properties of a membrane-bound dipeptidyl peptidase IV of guinea pig casein-induced intraperitoneal leukocytes: M. Kudo, et al.; J. Biochem. 97, 1211 (1985), Abstract;
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria: H. Umezawa, et al.; J. Antibiot. 37, 422 (1984), Abstract;

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