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Caspase inhibitor
ALX-260-029-M050 50 mg 594.00 USD
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Replaces Prod. #: BML-P415

Irreversible, cell permeable broad-spectrum caspase inhibitor.
Caspase-3 IC50: 1,1µM
Caspase-6 IC50: 4,1µM
Less effective on the inhibition of caspase-1- and 8-like activities.
Inhibits hypoxia-induced apoptosis in neuroblastoma cells.

Product Details

Alternative Name:Caspase family inhibitor, Z-Asp-CH2-DCB, Z-L-Asp-a-[2,6-(dichlorobenzoyl)oxy]methane
Purity:≥98% (TLC)
Appearance:White to off-white powder.
Solubility:Soluble in methanol (50mg/ml) or DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stock solutions should be divided into aliquots and stored at -20°C.
Handling:Keep cool and dry.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation: T. Krakauer; Clin. Diagn. Lab. Immunol. 11, 621 (2004), Abstract; Full Text
Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction: Y. Chandrashekhar, et al.; J. Am. Coll. Cardiol. 43, 295 (2004), Abstract;
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension: L. Taraseviciene-Stewart; FASEB J. 15, 427 (2001), Abstract; Full Text
Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest: C. Gajate, et al.; Cancer Res. 60, 2651 (2000), Abstract; Full Text
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer 86, 208 (2000), Abstract;
LPS-induced signals in activation of caspase-3-like protease, a key enzyme regulating apoptotic cell damage into a macrophage-like cell line, J774.1, in the presence of cycloheximide: H. Karahashi & F. Amano; J. Leukoc. Biol. 66, 689 (1999), Abstract; Full Text
Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells: U.K. Messmer et al.; Kidney Int. 55, 2322 (1999), Abstract; Full Text
Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria: R. Araya, et al.; FEBS Lett. 439, 168 (1998), Abstract;
Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells: T. Mashima, et al.; BBRC 209, 907 (1995), Abstract;
P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta- converting enzyme: R.E. Dolle, et al.; J. Med. Chem. 37, 563 (1994), Abstract;

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