Specific, highly fluorescent substrate for caspase-1. Also substrate for caspase-4.
Product Details
| Alternative Name: | Caspase-1 substrate (fluorogenic) |
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| Sequence: | Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH (Mca = (7-Methoxycoumarin-4-yl)acetyl; Dnp = Dinitrophenyl) |
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| Formula: | C53H64N10O19 |
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| MW: | 1145.1 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to yellow powder. |
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| Solubility: | Soluble in DMSO or 80% acetic acid (1mg/ml, with agitation). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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| Technical Info/Product Notes: | Mca has an excitation maximum of 325nm and an emission maximum of 392nm. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature
380, 723 (1996),
Abstract;
