Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Furin convertase inhibitor (chloromethylketone)

Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases.
ALX-260-022-M001 1 mg 217.00 USD
ALX-260-022-M005 5 mg 954.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: BML-PI132

Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases: furin/SPC1 (Ki~1nM), SPC2/PC2 (Ki=0.36nM), SPC3/PC1/PC3(Ki=2.0nM), SPC4/PACE4 (Ki=3.6nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki=0.12nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in various cell lines, including U87 and HT1080 cells. Typical concentration range used in tissue culture is 25-100µM.

Product Details

Alternative Name:Decanoyl-Arg-Val-Lys-Arg-chloromethylketone, Dec-RVKR-CMK, TACE inhibitor
Formula:C34H66N11O5Cl . 3TFA
MW:744.3 . 342.1
Purity:≥95% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in DMSO, methanol or water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
ALX-260-022 structure
Please mouse over
ALX-260-022 structure

Product Literature References

prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis: K.A. Dowd, et al.; PNAS 120, e2218899120 (2023), Abstract;
Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry: Y. Wan, et al.; J. Virol. 94, e02015 (2020), Application(s): Treatment of cell culture, Abstract; Full Text
Cleavage activates Dispatched for Sonic Hedgehog ligand release: D.P. Stewart, et al.; Elife 7, e31678 (2018), Abstract; Full Text
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity: J. Li, et al.; Cell 168, 86 (2017), Abstract;
Enhancing dengue virus maturation using a stable furin over-expressing cell line: S. Mukherjee, et al.; Virology 497, 33 (2016), Application(s): Cell culture, reduce the efficiency of prM cleavage in virus preparations, Abstract;
Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor: M. de Santi, et al.; Cell. Oncol. (Dordr.) 39, 149 (2016), Application(s): Treatment of HEK293 cells, Abstract;
Secreted factors from adipose tissue-derived mesenchymal stem cells suppress oxygen/glucose deprivation-induced cardiomyocyte cell death via furin/PCSK-like enzyme activity: Y. Tachida, et al.; Biochem. Biophys. Rep. 7, 266 (2016), Application(s): Furin/PCSK-like enzyme activity in synthetic substrate, Abstract; Full Text
Secretome Signature Identifies ADAM17 as Novel Target for Radiosensitization of Non-Small Cell Lung Cancer: A. Sharma, et al.; Clin. Cancer. Res. 22, 4428 (2016), Application(s): Cell culture, Abstract; Full Text
Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP: H. Kang, et al.; Biochem. Biophys. Res. Commun. 460, 596 (2015), Application(s): Cell Culture, Abstract;
PCSK6-mediated corin activation is essential for normal blood pressure: S. Chen, et al.; Nat. Med. 21, 1048 (2015), Application(s): Trypsin digestion, Abstract;
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases: J. Fu, et al.; Neoplasia 15, 169 (2013), Application(s): Western Blot, Abstract; Full Text
Proprotein Convertases Process and Thereby Inactivate Formylglycine-generating Enzyme: E. C. Ennemann, et al.; J. Biol. Chem. 288, 5828 (2013), Application(s): Cell Culture, Abstract; Full Text
Activation of the Epithelial Sodium Channel (ENaC) by the Alkaline Protease from Pseudomonas aeruginosa: M.B. Butterworth, et al.; J. Biol. Chem. 287, 32556 (2012), Application(s): Cell Culture, Abstract; Full Text
Decorin is Processed by Three Isoforms of Bone Morphogenetic Protein-1 (BMP1): Z. Von Marschall, et al.; Biochem. Biophys. Res. Commun. 391, 1374 (2010), Application(s): Cell Culture, Abstract; Full Text
In vitro and in vivo activation induces BAFF and APRIL expression in B cells: V.T. Chu, et al.; J. Immunol. 179, 5947 (2007), Application(s): Cell culture of mouse B cells, Abstract; Full Text
Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains: M. Fugere, et al.; J. Biol. Chem. 277, 7648 (2002), Abstract;
Shedding of the Transferrin Receptor Is Mediated Constitutively by an Integral Membrane Metalloprotease Sensitive to Tumor Necrosis Factor alpha Protease Inhibitor-2: M. Kaup, et al.; J. Biol. Chem. 277, 38494 (2002), Abstract; Full Text
Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide: S. Deb, et al.; J. Neurosci. Res. 55, 44 (1999), Abstract;
Furin-independent pathway of membrane type 1-matrix metalloproteinase activation in rabbit dermal fibroblasts: T. Sato; J. Biol. Chem. 274, 37280 (1999), Abstract;
alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent: F. Jean, et al.; PNAS 95, 7293 (1998), Abstract;
Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor: E. Maquoi, et al.; FEBS Lett. 424, 262 (1998), Abstract;
PACE4: a subtilisin-like endoprotease with unique properties: R.E. Mains, et al.; Biochem. J. 321, 587 (1997), Abstract;
Inhibition of convertase-related processing of proendothelin-1: J.B. Denault, et al.; J. Cardiovasc. Pharmacol. 26 Suppl 3, S47 (1995), Abstract;
Processing of proendothelin-1 by human furin convertase: J.B. Denault, et al.; FEBS Lett. 362, 276 (1995), Abstract;
Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin: M. Vey, et al.; Virology 206, 746 (1995), Abstract;
Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones: W. Garten, et al.; Biochimie 76, 217 (1994), Abstract;
The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast: H. Angliker, et al.; Biochem. J. 293, 75 (1993), Abstract;
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease: A. Stienke-Grober, et al.; EMBO J. 11, 2407 (1992), Abstract;
Inhibition of proteolytic activation of influenza virus hemagglutinin by specific peptidyl chloroalkyl ketones: W. Garten, et al.; Virology 172, 25 (1989), Abstract;

Related Products

Furin convertase substrate (fluorogenic) 

136132-77-9, ≥95% (HPLC; TLC) | Print as PDF
ALX-260-040-M001 1 mg 65.00 USD
ALX-260-040-M005 5 mg 145.00 USD
Do you need bulk/larger quantities?

Furin convertase (human) monoclonal antibody (MON-152) 

Ascites fluid from Balb/c mice as obtained after injection of MON-152 producing hybridoma cells and isolated using a physiological salt solution (0.9% NaCl)., ICC, IP, WB | Print as PDF
ALX-803-017-R100 100 µl 415.00 USD
Do you need bulk/larger quantities?

Product Toolbox


Certificate of Analysis


By target:
Proprotein convertase
By biological activity:
Proprotein convertase Inhibitor
By catalog section:


Technical Service
Customer Service