Product Specification
Alternative Name: | Dimethylarginine dimethylaminohydrolase 1, DDAH-1 |
|
Host: | Rabbit |
|
Immunogen: | Full length bovine dimethylargininase 1 (DDAH-1). |
|
UniProt ID: | P56965 |
|
Species reactivity: | Human, Mouse Bovine, Porcine
|
|
Crossreactivity: | Does not cross-react with DDAH-2. |
|
Applications: | WB
|
|
Recommended Dilutions/Conditions: | Western Blot (1:5,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
|
Application Notes: | Detects a band of ~35kDa by Western blot. |
|
Formulation: | Liquid. Neat serum. |
|
Handling: | Avoid freeze/thaw cycles. |
|
Shipping: | Shipped on Dry Ice |
|
Long Term Storage: | -20°C |
|
Scientific Background: | Dimethylargininase (DDAH) is a Cys-hydrolase, which, through catabolism of mono- and dimethylated derivatives of L-arginine, regulates the activity of nitric oxide synthase. DDAH-1 is mainly present in tissues expressing the constitutive forms of nitric oxide synthase such as brain and kidney. |
|
Regulatory Status: | RUO - Research Use Only |
|
Product Literature References
Toward the Development of Inhibitors Directed against Mammalian DDAH Proteins: Considerations from Homology Modeling of DDAH-2 and DDAH Activity Tracing in Tissue Homogenate: M. Knipp; Lett. Drug Des. Discov.
4, 570 (2007),
Abstract;
Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease: M.A. Smith, et al.; Free Radic. Biol. Med.
25, 898 (1998),
Abstract;