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HERG1A (NT) polyclonal antibody



ALX-215-050-R100	100 µl	408.00 USD
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Product Details

Alternative Name:	Ether-a-go-go related protein 1A, KCNH2 (isoform A), Voltage-gated potassium channel subfamily H member 2 (isoform A), Voltage-gated potassium channel Kv11.1 (isoform A), Erg1A

Host:	Rabbit

Immunogen:	Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1-135).

UniProt ID:	Q12809

Species reactivity:	Human, Mouse

Specificity:	Recognizes N-terminal epitope of HERG1A and mouse Erg1A isoform.

Recommended Dilutions/Conditions:	Immunocytochemistry (1:50-1:200) Immunohistochemistry (frozen sections and paraffin sections, 1:100-1:400) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Formulation:	Liquid. Neat serum.

Handling:	Avoid freeze/thaw cycles.

Shipping:	Blue Ice

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Scientific Background:	The ether-a-go-go related gene family of K⁺ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.

Regulatory Status:	RUO - Research Use Only

Product Literature References

HERG1A potassium channel is the predominant isoform in head and neck squamous cell carcinomas: evidence for regulation by epigenetic mechanisms: S. T. Menendez, et al.; Sci. Rep. 6, 19666 (2016), Application(s): Immunohistochemistry, Abstract; Full Text

Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005), Abstract;

Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005), Abstract; Full Text

Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005), Abstract;

Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells: O. Crociani, et al.; J. Biol. Chem. 278, 2947 (2003), Abstract; Full Text

HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium: A. Cherubini, et al.; Br. J. Cancer 83, 1722 (2000), Abstract;