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Epstein-Barr Virus-induced Gene 3 (human) polyclonal antibody (AT136)

ALX-210-962-C100 100 µg 374.00 USD
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Product Specification

Alternative Name:IL-27B, Interleukin-27 subunit β, EBV-induced gene 3 protein, IL-27 subunit β, EBI3
Immunogen:Recombinant human EBI3 (aa 21-229).
UniProt ID:Q14213
Source:Purified from rabbit serum.
Species reactivity:Human
Recommended Dilutions/Conditions:Western blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein A-affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:EBI3 (Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein; IL-27B; IL-27 subunit β) and IL-12A (IL-12 subunit p35; CLMF p35) form the heterodimeric cytokine IL-35 (interleukin-35) involved in T cell regulation.
Regulatory Status:RUO - Research Use Only

General Literature References

IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells: W. Niedbala, et al.; Eur. J. Immunol. 37, 3021 (2007), Abstract; Full Text
The inhibitory cytokine IL-35 contributes to regulatory T-cell function: L.W. Collison, et al.; Nature 450, 566 (2007), Abstract;
Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin: O. Devergne, et al.; PNAS 94, 12041 (1997), Abstract; Full Text

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