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AROS (human) polyclonal antibody (AT135)

ALX-210-961-C100 100 µg 385.00 USD
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Product Specification

Alternative Name:Active regulator of SIRT1
Immunogen:Recombinant human AROS (aa 2-136).
UniProt ID:Q86WX3
Source:Purified from rabbit serum.
Species reactivity:Human
Recommended Dilutions/Conditions:Western blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Protein A-affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:SIRT1 is a member of the silent information regulator 2 (Sir2) family. It is an NAD+-dependent deacetylase protein that functions in cell death / survival, senescence, and endocrine signaling. It is also involved in the increase of life span following caloric restriction. Recently, the first direct activator of SIRT1 has been described: AROS (active regulator of SIRT1). This nuclear protein of 142 amino acids interacts with SIRT1 and enhances SIRT1-mediated deacetylation of p53.
Regulatory Status:RUO - Research Use Only

General Literature References

Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity: E.J. Kim, et al.; Mol. Cell 28, 277 (2007), Abstract;
Sirtuins: Sir2-related NAD-dependent protein deacetylases: B.J. North & E. Verdin; Genome Biol. 5, 224 (2004), Abstract; Full Text

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