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WIPI-1 polyclonal antibody (AT130)

 
ALX-210-955-C100 100 µg 383.00 USD
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Product Specification

Alternative Name:WD repeat domain phosphoinositide-interacting protein 1, WD40 repeat protein interacting with phosphoinositides of 49kDa, Atg18 protein homolog, WIPI 49kDa
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa in the middle of human WIPI-1.
 
UniProt ID:Q5MNZ9
 
Source:Purified from rabbit serum.
 
Species reactivity:Human, Mouse
 
Applications:WB
 
Recommended Dilutions/Conditions:Western blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Epitope-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:WIPI-1 (WD-repeat protein interacting with phosphoinosides) is highly expressed in a variety of tumors. It interacts with phosphatidylinositol-3-P and this interaction is required for recruitment to membranes. WIPI-1 contains the signature motif LXXLL for nuclear receptor association and it binds to estrogen and androgen receptors in vitro. The WIPI-1 homolog in S. cerevisiae (Atg18) plays a role in autophagy. WIPI-1 accumulates in multi-membrane structures under autophagic conditions and it co-localizes with LC3.
 
Regulatory Status:RUO - Research Use Only
 

General Literature References

Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy: T. Proikas-Cezanne, et al.; FEBS Lett. 581, 3396 (2007), Abstract;

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