Product Details
| Alternative Name: | GAAD, Granzyme A-activated DNase, NDPKA, NME1 NME2 |
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| Host: | Rabbit |
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| Immunogen: | Recombinant human NM23-H1. |
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| UniProt ID: | P15531 |
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| Species reactivity: | Human, Mouse
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| Specificity: | Recognizes NM23-H1 and NM23-H2. |
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| Crossreactivity: | NM23-H2. |
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| Applications: | ICC, IHC (PS), WB
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| Recommended Dilutions/Conditions: | Immunocytochemistry (1:100)
Immunohistochemistry (paraffin sections, 1:200)
Western Blot (1:100-1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Purity Detail: | Protein A-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility: L. Garzia, et al.; Oncogene
27, 1853 (2008),
Abstract;
Full Text
Overexpression of h-prune in breast cancer is correlated with advanced disease status: M. Zollo, et al.; Clin. Cancer Res.
11, 199 (2005),
Abstract;
Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis: A. D'Angelo, et al.; Cancer Cell
5, 137 (2004),
Abstract;
General Literature References
The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal: J. Lieberman; Nat. Rev. Immunol.
3, 361 (2003),
Abstract;
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor: Z. Fan, et al.; Cell
112, 659 (2003),
Abstract;
Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity: A. Forus, et al.; Oncogene
20, 6881 (2001),
Abstract;
Evidence for interaction between human PRUNE and nm23-H1 NDPKinase: A. Reymond, et al.; Oncogene
18, 7244 (1999),
Abstract;
