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NLRP1/NALP1 (human) polyclonal antibody (AL176)

ALX-210-904-R100 100 µl 399.00 USD
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Product Details

Alternative Name:NACHT-, LRR- and PYD-containing protein 1, DEFCAP, NAC, CARD7, Caspase recruitment domain-containing protein 7
Immunogen:Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) of N-terminal human NLRP1/NALP1 (NACHT-, LRR- and PYD-containing protein 1).
UniProt ID:Q9C000
Species reactivity:Human
Crossreactivity:Does not cross-react with mouse NLRP1/NALP1.
Formulation:Liquid. Neat serum containing 0.02% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored as recommended.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
NLRP1/NALP1 (human) polyclonal antibody (AL176) Western blot
Figure: Western blot analysis of human and mouse  cell lines with the anti-human NLRP1/NALP1 antibody (AL176) (Prod. No. ALX-210-904).Method: Total protein extracts (20µg) from various human (293-T, Jurkat, Raj, Ramos, BJAB, THP-1, U937, K562, Raw, HeLa) and mouse (EL-4, A20) cell lines were run on SDS-PAGE and NLRP1/NALP1 detected by Prod. No. ALX-210-904 at 1:500 dilution. Anti-rabbit IgG coupled horse radish peroxidase was used at 1:5000 dilution for ECL detection. "
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NLRP1/NALP1 (human) polyclonal antibody (AL176) Western blot

Product Literature References

Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer’s disease: R.T. Vontell, et al.; Brain Pathol. 33, e13142 (2023), Abstract;
HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome: O. Plazyo, et al.; Biol. Reprod. 95, 130 (2016), Application(s): Western blot, Abstract;
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon; Mol. Cell. 10, 417 (2002), Abstract;

General Literature References

NALPS: a novel protein family involved in inflammation: J. Tschopp, et al.; Nat. Rev. Mol. Cell Biol. 4, 95 (2003), (Review), Abstract; Full Text
Signalling: Initiation of pro-IL-1beta processing: E. Bell; Nat. Rev. Immunol. 2, 719 (2002), (Review), Abstract;
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1: S.M. Srinivasula, et al.; J. Biol. Chem. 277, 21119 (2002), Abstract;