Product Details
| Alternative Name: | NACHT-, LRR- and PYD-containing protein 1, DEFCAP, NAC, CARD7, Caspase recruitment domain-containing protein 7 |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) of N-terminal human NLRP1/NALP1 (NACHT-, LRR- and PYD-containing protein 1). |
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| UniProt ID: | Q9C000 |
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| Species reactivity: | Human
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| Crossreactivity: | Does not cross-react with mouse NLRP1/NALP1. |
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| Applications: | WB
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| Formulation: | Liquid. Neat serum containing 0.02% sodium azide. |
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| Use/Stability: | Stable for at least 1 year after receipt when stored as recommended. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Western blot analysis of human and mouse cell lines with the anti-human NLRP1/NALP1 antibody (AL176) (Prod. No.
ALX-210-904).
Method: Total protein extracts (20µg) from various human (293-T, Jurkat, Raj, Ramos, BJAB, THP-1, U937, K562, Raw, HeLa) and mouse (EL-4, A20) cell lines were run on SDS-PAGE and NLRP1/NALP1 detected by Prod. No.
ALX-210-904 at 1:500 dilution. Anti-rabbit IgG coupled horse radish peroxidase was used at 1:5000 dilution for ECL detection. "
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Product Literature References
Identification of inflammasome signaling proteins in neurons and microglia in early and intermediate stages of Alzheimer’s disease: R.T. Vontell, et al.; Brain Pathol.
33, e13142 (2023),
Abstract;
HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome: O. Plazyo, et al.; Biol. Reprod.
95, 130 (2016),
Application(s): Western blot,
Abstract;
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon; Mol. Cell.
10, 417 (2002),
Abstract;
General Literature References
NALPS: a novel protein family involved in inflammation: J. Tschopp, et al.; Nat. Rev. Mol. Cell Biol.
4, 95 (2003), (Review),
Abstract;
Full Text
Signalling: Initiation of pro-IL-1beta processing: E. Bell; Nat. Rev. Immunol.
2, 719 (2002), (Review),
Abstract;
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1: S.M. Srinivasula, et al.; J. Biol. Chem.
277, 21119 (2002),
Abstract;
