Malondialdehyde polyclonal antibody



ALX-210-879-R100	100 µl	765.00 USD
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Product Details

Alternative Name:	MDA

Host:	Rabbit

Immunogen:	Malondialdehyde (MDA) conjugated to KLH.

Species reactivity:	Species independent

Specificity:	Recognizes MDA adducts.

Applications:	ELISA, IHC, WB

Recommended Dilutions/Conditions:	ELISA (1:1,000-1:10,000) Immunohistochemistry (1:500-1:1,000) Western blot (1:500-1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Purity Detail:	Unpurified

Formulation:	Liquid. Contains 0.1% sodium azide.

Use/Stability:	Do not freeze, thaw or store diluted working solutions.

Handling:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Shipping:	Blue Ice

Long Term Storage:	-20°C

Scientific Background:	MDA (Malondialdehyde) is a highly reactive three carbon dialdehyde produced as a byproduct of polyunsaturated fatty acid peroxidation and arachidonic acid metabolism. MDA readily combines with several functional groups on molecules including proteins, lipoproteins, and DNA. MDA modified proteins may show altered physico-chemical behavior and antigenicity. Antibodies to MDA will help to visualize the MDA-adducts.

Regulatory Status:	RUO - Research Use Only

Product Literature References

Epigallocatechin-3-gallate protects against hepatic ischaemia-reperfusion injury by reducing oxidative stress and apoptotic cell death: E. Tak, et al.; J. Int. Med. Res. 44, 1248 (2016), Application(s): Western blot, Abstract; Full Text

Glomerular malondialdehyde levels in patients with focal and segmental glomerulosclerosis and minimal change disease: S.T. Nezhad, et al.; Saudi J. Kidney Dis.Transpl. 21, 886 (2010), Abstract; Full Text

Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury.: M. Penkowa, et al.; Exp. Neurol. 181, 130 (2003), Abstract;

Role of metallothionein-III following central nervous system damage.: J. Carrasco, et al.; Neurobiol. Dis. 13, 22 (2003), Abstract;

Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis.: M. Penkowa, et al.; J. Neuroimmunol. 119, 248 (2001), Abstract;

Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.: M. Penkowa, et al.; Neuroscience 102, 805 (2001), Abstract;

Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice.: J. Carrasco, et al.; Eur. J. Neurosci. 12, 2311 (2000), Abstract;