Product Details
| Alternative Name: | TLR7 |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 706-728 of human TLR7 (Toll-like receptor 7). |
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| UniProt ID: | Q9NYK1 |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | Flow Cytometry, ICC, IHC (FS), IHC (PS), IP, WB
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| Recommended Dilutions/Conditions: | Flow Cytometry (intracellular, 0.5-5µg/106 cells)
Immunohistochemistry (paraffin sections, 5-10µg/ml)
Western Blot (1-3µg/ml) |
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| Application Notes: | Flow Cytometry: suitable for cell surface and intracellular FC.
Western Blot: in human Ramos cells, additional bands are seen |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. |
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| Use/Stability: | Stable for 6 months when stored at +4°C. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Figure 1: Western blot analysis of TLR7 in Raw cell lysate using Prod. No.
ALX-210-874 at 1µg/ml. "
Figure 2: Intracellular staining by FACS analysis of TLR7 in Ramos cells (A) and Raw cells (B) using Prod. No.
ALX-210-874 at 2µg/ml. Histogram C shows the rabbit IgG isotype control."
Figure 3: Immunohistochemical analysis of human colon tissue using PAb to Toll-like Receptor 7 (Prod. No.
ALX-210-874) and an isotype control (bottom) at 5μg/ml."
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Product Literature References
Antitumor effects of imidazoquinolines in urothelial cell carcinoma of the bladder: E.B. Smith, et al.; J. Urol.
177, 2347 (2007),
Abstract;
Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract: M.A. Palladino, et al.; Biol. Reprod.
76, 958 (2007),
Abstract;
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling: M.M. Brinkmann, et al.; J. Cell Biol.
177, 265 (2007),
Abstract;
Full Text
Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice: P.S. Patole, et al.; Nephrol. Dial. Transplant.
21, 3062 (2006),
Abstract;
Toll-like receptor-7 modulates immune complex glomerulonephritis: R.D. Pawar, et al.; J. Am. Soc. Nephrol.
17, 141 (2006),
Abstract;
Full Text
Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line: M.D. Srivastava and B.I. Srivastava; Leuk. Res.
29, 813 (2005),
Abstract;
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad: S. Francois, et al.; J. Immunol.
174, 3633 (2005),
Abstract;
TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production: O.M. Hart, et al.; J. Immunol.
175, 1636 (2005),
Abstract;
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