Product Details
| Alternative Name: | sGCα1β1 |
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| Host: | Chicken |
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| Immunogen: | Purified rat lung soluble guanylyl cyclase α1β1 (sGCα1β1) (native protein). |
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| UniProt ID: | P19686 |
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| Species reactivity: | Human, Mouse, Rat
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| Specificity: | Recognizes endogenous rat sGCα1β1. Recognizes human and mouse sGCβ1. |
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| Crossreactivity: | Does not cross-react with human and mouse sGCα1. |
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot(1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Western Blot: Works on endogenous
Not recommended for the detection of human and mouse sGCα1 subunits, because of the lack of sensitivity. |
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| Purity Detail: | Purified IgY from egg yolk. |
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| Formulation: | Liquid. In 10mM TRIS-HCl, pH 7.5, containing 150mM sodium chloride and 0.02% thimerosal. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Down-regulation of soluble guanylyl cyclase expression by cyclic AMP is mediated by mRNA-stabilizing protein HuR: S. Kloss, et al.; Mol. Pharmacol.
65, 1440 (2004),
Abstract;
Full Text
Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aorta: S. Kloss, et al.; J. Biol. Chem.
278, 2377 (2003),
Abstract;
Full Text
Tissue distribution of the human soluble guanylate cyclases: J. Budworth, et al.; BBRC
263, 6967 (1999),
Abstract;
Human soluble guanylate cyclase: functional expression and revised isoenzyme family: U. Zabel, et al.; Biochem. J.
335, 51 (1998),
Abstract;
Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclase: J.R. Stone, et al.; BBRC
207, 572 (1995),
Abstract;
Functional domains of soluble guanylyl cyclase: B. Wedel, et al.; J. Biol. Chem.
270, 24871 (1995),
Abstract;
Full Text
Regulation of vascular smooth muscle soluble guanylate cyclase activity, mRNA, and protein levels by cAMP-elevating agents: A. Papapetropoulos, et al.; Hypertension
26, 696 (1995),
Abstract;
Full Text
Homologous and heterologous desensitization of a guanylyl cyclase-linked nitric oxide receptor in cultured rat medullary interstitial cells: K. Ujiie, et al.; J. Pharmacol. Exp. Ther.
270, 761 (1994),
Abstract;
cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts: A. Shimouchi, et al.; Am. J. Physiol.
265, L456 (1993),
Abstract;
Intracellular cyclic GMP receptor proteins: T.M. Lincoln and T.L. Cornwell; FASEB J.
7, 328 (1993),
Abstract;
Full Text
The nitric oxide and cGMP signal transduction system: regulation and mechanism of action: H.H. Schmidt, et al.; Biochim. Biophys. Acta
1178, 153 (1993),
Abstract;
Soluble guanylate cyclase purified from bovine lung contains heme and copper: R. Gerzer, et al.; FEBS Lett.
132, 71 (1981),
Abstract;
