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Guanylyl cyclase α1β1 (soluble) polyclonal antibody

ALX-210-786-R100 100 µl 426.00 USD
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Product Details

Alternative Name:sGCα1β1
Immunogen:Purified rat lung soluble guanylyl cyclase α1β1 (sGCα1β1) (native protein).
UniProt ID:P19686
Species reactivity:Human, Mouse, Rat
Specificity:Recognizes endogenous rat sGCα1β1. Recognizes human and mouse sGCβ1.
Crossreactivity:Does not cross-react with human and mouse sGCα1.
Recommended Dilutions/Conditions:Western Blot(1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Western Blot: Works on endogenous
Not recommended for the detection of human and mouse sGCα1 subunits, because of the lack of sensitivity.
Purity Detail:Purified IgY from egg yolk.
Formulation:Liquid. In 10mM TRIS-HCl, pH 7.5, containing 150mM sodium chloride and 0.02% thimerosal.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Down-regulation of soluble guanylyl cyclase expression by cyclic AMP is mediated by mRNA-stabilizing protein HuR: S. Kloss, et al.; Mol. Pharmacol. 65, 1440 (2004), Abstract; Full Text
Post-transcriptional regulation of soluble guanylyl cyclase expression in rat aorta: S. Kloss, et al.; J. Biol. Chem. 278, 2377 (2003), Abstract; Full Text
Tissue distribution of the human soluble guanylate cyclases: J. Budworth, et al.; BBRC 263, 6967 (1999), Abstract;
Human soluble guanylate cyclase: functional expression and revised isoenzyme family: U. Zabel, et al.; Biochem. J. 335, 51 (1998), Abstract;
Electron paramagnetic resonance spectral evidence for the formation of a pentacoordinate nitrosyl-heme complex on soluble guanylate cyclase: J.R. Stone, et al.; BBRC 207, 572 (1995), Abstract;
Functional domains of soluble guanylyl cyclase: B. Wedel, et al.; J. Biol. Chem. 270, 24871 (1995), Abstract; Full Text
Regulation of vascular smooth muscle soluble guanylate cyclase activity, mRNA, and protein levels by cAMP-elevating agents: A. Papapetropoulos, et al.; Hypertension 26, 696 (1995), Abstract; Full Text
Homologous and heterologous desensitization of a guanylyl cyclase-linked nitric oxide receptor in cultured rat medullary interstitial cells: K. Ujiie, et al.; J. Pharmacol. Exp. Ther. 270, 761 (1994), Abstract;
cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts: A. Shimouchi, et al.; Am. J. Physiol. 265, L456 (1993), Abstract;
Intracellular cyclic GMP receptor proteins: T.M. Lincoln and T.L. Cornwell; FASEB J. 7, 328 (1993), Abstract; Full Text
The nitric oxide and cGMP signal transduction system: regulation and mechanism of action: H.H. Schmidt, et al.; Biochim. Biophys. Acta 1178, 153 (1993), Abstract;
Soluble guanylate cyclase purified from bovine lung contains heme and copper: R. Gerzer, et al.; FEBS Lett. 132, 71 (1981), Abstract;

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