Product Details
Alternative Name: | C-C chemokine receptor 4, CD194 |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to aa 8-26 (D8TTQDETVYNSYYFY ESMP26) of the N-terminal extracellular domain of mouse CCR4 (C-C chemokine receptor 4). |
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UniProt ID: | P51680 |
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Species reactivity: | Mouse
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Crossreactivity: | Does not cross-react with human CCR4. |
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Applications: | ICC, IHC (PS), WB
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Recommended Dilutions/Conditions: | Immunocytochemistry (1:500) Western Blot (1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Purity Detail: | Epitope-affinity purified F(ab')2 fragment. |
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Quality Control: | Immunocytochemistry on mouse spleen cells. |
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Formulation: | Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide. |
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Handling: | For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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Shipping: | Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | Mouse CCR4 is the homolog of human CCR4 receptor (85% identical), binding macrophage inflammatory protein-1α (MIP-1α) and RANTES. Mouse CCR4 transcripts are expressed in the thymus and in T-cell lines. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Dendritic cell immunization route determines CD8+ T cell trafficking to inflamed skin: role for tissue microenvironment and dendritic cells in establishment of T cell-homing subsets: J.C. Dudda, et al.; J. Immunol.
172, 857 (2004),
Abstract;
General Literature References
Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4: A. Hoogewerf, et al.; BBRC
218, 337 (1996),
Abstract;