Product Details
Alternative Name: | Nuclear factor of activated T cells, cytoplasmic 2, NFAT1, NFATP |
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Host: | Rabbit |
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Immunogen: | Recombinant human NF-ATc2 protein fused to GST. |
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UniProt ID: | Q13469 |
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Species reactivity: | Human
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Crossreactivity: | May contain some residual anti-GST activity. |
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Applications: | IHC (PS), IP, WB ChIP
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Recommended Dilutions/Conditions: | Immunohistochemistry (formaldehyde fixed paraffin sections, 1:50) Chromatin Immunoprecipitation (1:100) Western Blot (1:500). The recommended dilutions refer to the analysis of cells and tissues with intermediate to high levels of NF-ATc2 and must be viewed as approximate Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Purity Detail: | Affinity purified. |
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Formulation: | Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. |
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Handling: | Avoid freeze/thaw cycles. |
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Shipping: | Blue Ice |
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Short Term Storage: | +4°C |
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Long Term Storage: | -20°C |
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Technical Info/Product Notes: | Note: Confusion may arise regarding NFAT protein versus gene names. According to UniProt, the nomenclature is as follows:Nuclear Factor of Activated T Cells, Cytoplasmic 1 (NF-ATc1)Gene Names: NFATC1 or NFATC or NFAT2 Nuclear Factor of Activated T Cells, Cytoplasmic 2 (NF-ATc2)Gene Names: NFATC2 or NFATP or NFAT1 Nuclear Factor of Activated T Cells, Cytoplasmic 3 (NF-ATc3)Gene Names: NFATC3 or NFATX or NFAT4 Nuclear Factor of Activated T Cells, Cytoplasmic 4 (NF-ATc4)Gene Names: NFATC4 or NFAT3 Nuclear Factor of Activated T Cells (NF-AT5)Gene Names: NFAT5 |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling: A. Akimzhanov, et al.; Am. J. Pathol.
172, 215 (2008),
Abstract;
NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells: E. Ulleras, et al.; Blood
111, 3081 (2008),
Abstract;
Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines: M. Klein, et al.; J. Immunol.
177, 6667 (2006),
Abstract;
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