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NF-ATc2 polyclonal antibody

ALX-210-578-C020 20 µg 646.00 USD
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Product Details

Alternative Name:Nuclear factor of activated T cells, cytoplasmic 2, NFAT1, NFATP
Immunogen:Recombinant human NF-ATc2 protein fused to GST.
UniProt ID:Q13469
Species reactivity:Human
Crossreactivity:May contain some residual anti-GST activity.
Applications:IHC (PS), IP, WB
Recommended Dilutions/Conditions:Immunohistochemistry (formaldehyde fixed paraffin sections, 1:50)
Chromatin Immunoprecipitation (1:100)
Western Blot (1:500).
The recommended dilutions refer to the analysis of cells and tissues with intermediate to high levels of NF-ATc2 and must be viewed as approximate
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Affinity purified.
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Technical Info/Product Notes:Note: Confusion may arise regarding NFAT protein versus gene names. According to UniProt, the nomenclature is as follows:Nuclear Factor of Activated T Cells, Cytoplasmic 1 (NF-ATc1)Gene Names: NFATC1 or NFATC or NFAT2
Nuclear Factor of Activated T Cells, Cytoplasmic 2 (NF-ATc2)Gene Names: NFATC2 or NFATP or NFAT1
Nuclear Factor of Activated T Cells, Cytoplasmic 3 (NF-ATc3)Gene Names: NFATC3 or NFATX or NFAT4
Nuclear Factor of Activated T Cells, Cytoplasmic 4 (NF-ATc4)Gene Names: NFATC4 or NFAT3
Nuclear Factor of Activated T Cells (NF-AT5)Gene Names: NFAT5
Regulatory Status:RUO - Research Use Only

Product Literature References

Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling: A. Akimzhanov, et al.; Am. J. Pathol. 172, 215 (2008), Abstract;
NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells: E. Ulleras, et al.; Blood 111, 3081 (2008), Abstract;
Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines: M. Klein, et al.; J. Immunol. 177, 6667 (2006), Abstract; Full Text

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