Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

O6-Methylguanine-DNA methyltransferase polyclonal antibody

ALX-210-551-R100 100 µl 220.00 USD
Do you need bulk/larger quantities?

Product Specification

Alternative Name:MGMT
Immunogen:Human MGMT (O6-methylguanine-DNA methyltransferase).
UniProt ID:P16455
Species reactivity:Human, Mouse, Rat
Recommended Dilutions/Conditions:Western Blot (1:100-1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Formulation:Contains 0.05% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:O6-Methylguanine-DNA methyltransferase (MGMT) removes O6-methylguanine from DNA by transferring the O6-alkyl group to a specific cysteine residue within its own sequence irreversibly inactivating MGMT. Unrepaired alkylated guanine will cause G·C -> A·T transition mutations by anomalous base pairing during DNA replication. DNA damage by O6-methylguanine can induce apoptosis regulated by Bcl-2 and caspases- 3 & -9. MGMT is able to remove O4-alkylated-thymine.

Product Literature References

O6-methylguanine-DNA methyltransferase activity in breast and brain tumors: I. Preuss, et al.; Int. J. Cancer 61, 321 (1995), Abstract;

Related Literature

Stem Cells
Stem Cells
Download as PDF

Download as PDF

All new literature pieces

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2020 Enzo Life Sciences, Inc.,