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SOCS-1 polyclonal antibody



ALX-210-392-R200	200 µl	221.00 USD
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Product Details

Alternative Name:	JAB, SSI-1, TIP-3, Suppressor of cytokine signaling-1

Host:	Rabbit

Immunogen:	Synthetic peptide corresponding to aa 54-68 of human SOCS-1 (suppressor of cytokine signalling-1).

UniProt ID:	O15524

Species reactivity:	Human, Mouse

Applications:	WB

Recommended Dilutions/Conditions:	Western Blot (1:500 - 1:1,000) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Purity Detail:	Protein G-affinity purified.

Formulation:	Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.

Handling:	Avoid freeze/thaw cycles.

Shipping:	Blue Ice

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Scientific Background:	SOCS-1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signalling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin. SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signalling.

Regulatory Status:	RUO - Research Use Only

Figure: Western blot analysis of SOCS-1 using Prod. No. ALX-210-392 at 1:1000 dilution against 15 mg/lane of Ramos (A) and Raw (B) cell lysate."

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General Literature References

A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts: S. Ilangumaran, et al.; J. Immunol. 169, 5010 (2002), Abstract;

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation: I. Kinjyo, et al.; Immunity 17, 583 (2002), Abstract;

SOCS proteins: negative regulators of cytokine signaling: D.L. Krebs and D.J. Hilton; Stem Cells 19, 378 (2001), Abstract;