Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Munc-18 polyclonal antibody

ALX-210-247-C100 100 µg 577.00 USD
Do you need bulk/larger quantities?

Product Details

Immunogen:Synthetic peptide corresponding to aa 58-70 (V58EDINKRREPIPS70) of human Munc-18.
UniProt ID:P61764 (Munc-18-1), Q15833 (Munc-18-2)
Species reactivity:Mouse, Rat
Applications:IHC (FS), IP, WB
Recommended Dilutions/Conditions:Western Blot (1µg/ml)
Application Notes:Detects a band of ~67kDa by Western blot.
Purity Detail:Epitope-affinity purified IgG.
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Munc-18 is a cytosolic brain protein of ~67kDa which plays a key role in vesicle membrane fusion events with the plasma membrane. Functional interactions have been demonstrated to exist between Munc-18, SNAP-25, synaptobrevin, and syntaxin. Munc-18 is the mammalian homologue of the C. elegans gene unc-18. Mutations in unc-18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect. Munc-18 thus appears to be required by the synaptic vesicle fusion complex. Two Munc-18 isoforms have been identified. Munc-18-1 has been shown to be primarily expressed in brain, while Munc-18-2 is expressed in most tissues.
Regulatory Status:RUO - Research Use Only
Munc-18 polyclonal antibody Western blot
Figure 1: Western blot of Munc-18 in rat brain homogenate immunoprecipitated with Munc-18, pAb (Prod. No. ALX-210-247).
Lane 1: Extract only.
Lanes: 2-4. 750µg of extract immunoprecipitated with 1µg, 5µg, and 10µg of ALX-210-247, respectively.
Please mouse over
Munc-18 polyclonal antibody Western blot

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
Munc Polyclonal antibody
By catalog section:


Technical Service
Customer Service

Related Literature

Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

All new literature pieces