Replaces Prod. #: ALX-210-143/1
Product Details
| Alternative Name: | CASR |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 12-27 (A12LAWHSSAYGPDQRAQ27) of rat CASR (Ca2+-sensing receptor). |
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| UniProt ID: | P48442 |
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| Species reactivity: | Human, Rat
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| Applications: | WB
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| Recommended Dilutions/Conditions: | Western Blot (1:100) |
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| Application Notes: | Detects a band of ~120kDa by Western blot. |
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| Purity Detail: | Epitope-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.05% sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | The calcium sensing receptor (CASR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Based on sequence analysis of cDNA clones it appears that the CASR is similar to the 7-transmembrane-domain G-protein-coupled receptor superfamily. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CASR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo). |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium: S.E. McNeil, et al.; J. Biol. Chem.
273, 1114 (1998),
Abstract;
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