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Furin convertase polyclonal antibody

ALX-210-134-R100 100 µl 778.00 USD
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Product Details

Immunogen:Synthetic peptide corresponding to aa 780-793 (R780GERTAFIKDQSAL793) of C-terminal human furin.
UniProt ID:P09958
Species reactivity:Mouse
Specificity:Recognizes mouse and dog furin convertase and overexpressed human furin convertase. Does not detect endogenous furin from BSC-40, HeLa, J774A-1 BPAEC or CHO cells.
Crossreactivity:Does not cross-react with rat furin convertase.
Applications:ICC, IF, IP, WB
Recommended Dilutions/Conditions:Immunoprecipitation (1:100)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Immunocytochemical staining of endogenous furin convertase in 3T3 cells with Prod. No. ALX-210-134 yields a pattern consistent with paranuclear staining.
Detects a band of ~100kDa by Western blot.
Purity Detail:Epitope-affinity purified IgG.
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
Furin convertase polyclonal antibody ICC
Figure: Immunolocalization of endogenous furin in mouse 3T3 cells using PAb to Furin Convertase (Prod. No. ALX-210-134)."
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Furin convertase polyclonal antibody ICC

Product Literature References

Shedding of membrane type matrix metalloproteinase 5 by a furin-type convertase: a potential mechanism for down-regulation: X. Wang & D. Pei; J. Biol. Chem. 276, 35953 (2001), Abstract; Full Text
Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway: G. Liu, et al.; J. Cell Biol. 139, 1719 (1997), Abstract; Full Text

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