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Fis1 polyclonal antibody

ALX-210-1037-0100 100 µg 434.00 USD
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Replaces Prod. #: ALX-210-907

Product Details

Alternative Name:Mitochondrial fission 1
Immunogen:Synthetic peptide surrounding aa 143 of human Fis1.
UniProt ID:Q9Y3D6
Species reactivity:Human, Mouse, Rat
Recommended Dilutions/Conditions:Western Blot (1-4 µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Affinity purified.
Formulation:Liquid. In PBS containig 0.5% BSA, 0.01% thimerosal and 30% glycerol.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:The human Fis1, mitochondrial fission 1, is a novel molecule that was discovered as part of the mammalian fission machinery. Fis1 has been suggested to play a role in regulation of the fission processes that might be involved in apoptotic mechanisms.
Regulatory Status:RUO - Research Use Only
Fis1 polyclonal antibody Western blot
Western blot analysis of Fis1 pAb (Prod. No. ALX-210-1037) with Jurkat cell lysates.
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Fis1 polyclonal antibody Western blot

Product Literature References

The fasting-feeding metabolic transition regulates mitochondrial dynamics: M. Castro-Sepúlveda, et al.; FASEB J. 35, e21891 (2021), Abstract;
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats: J.C.B. Ferreira, et al.; Nat. Commun. 10, 329 (2019), Abstract; Full Text
Fis1 deficiencies differentially affect mitochondrial quality in skeletal muscle: Z. Zhang, et al.; Mitochondrion 49, 217 (2019), Abstract; Full Text
Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway: Y. Yu, et al.; Free Radic. Biol. Med. 112, 397 (2017), Application(s): Western Blot, Abstract;
Severe encephalopathy associated to pyruvate dehydrogenase mutations and unbalanced coenzyme Q10 content: C. Asencio, et al.; Eur. J. Hum. Genet. 24, 367 (2016), Application(s): Western Blot, Abstract;
Sprague Dawley rats: a model of successful heart aging: D. Capitanio, et al.; EuPA Open Proteom. 12, 22 (2016), Application(s): Immunoblotting, Abstract; Full Text
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice: M. Yue, et al.; Neurobiol. Dis. 78, 172 (2015), Application(s): Western Blot, Abstract;

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